DIFFERENTIATION OF STEM CELLS TO PANCREATIC ENDOCRINE CELLS

Patent Number: WO-2024008810-A1

Publication Year: 2024

Application Year: 2023

Priority Year: 2022

Jurisdictions: WO

Status: N/A

Inventors:

HONORÉ CHRISTIAN DJORDJEVIC DJORDJE WILLENBROCK HANNI KLEIBER THOMAS KIRKEGAARD JEANNETTE

Applicants:

  1. Novo Nordisk (Denmark)
  2. [NORA names: Novo Nordisk; Private Research; Denmark; Europe, EU; Nordic; OECD]

Abstract

An in vitro method for producing a population of pancreatic endocrine (PEC) cells comprising the steps of i) differentiating a population of pancreatic endoderm (PE) cells into pancreatic endocrine progenitors, in which the differentiating comprises treating the pancreatic endoderm (PE) cells with an inhibitor of Vascular Endothelial Growth Factor (VEGF) receptor and/or Platelet-Derived Growth Factor (PDGF) receptor, and ii) differentiating the pancreatic endocrine progenitor (EP) cells into pancreatic endocrine (PEC) cells by treating the pancreatic endocrine progenitor (EP) cells with an inhibitor of Vascular Endothelial Growth Factor (VEGF) receptor and/or Platelet-Derived Growth Factor (PDGF) receptor.

Patent Family Records (1)

DIFFERENTIATION OF STEM CELLS TO PANCREATIC ENDOCRINE CELLS

NOVO NORDISK AS, Novo Nordisk (Denmark) HONORÉ CHRISTIAN, DJORDJEVIC DJORDJE, WILLENBROCK HANNI, (...more)

2024, WO-2024008810-A1

Data Provider: Digital Science